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Drug reaction
After analyzing and identifying the source of the reaction, our expert dermatologists offer suitable treatments.
Synonyms: ■ Exanthematous drug eruption: morbilliform, maculopapular or urticarial drug eruption ■ Drug reaction with eosinophilia and systemic symptoms (DRESS): hypersensitivity syndrome ■ Acute generalized exanthematous pustulosis (AGEP): pustular drug eruption, toxic pustuloderma.
Key features
• The skin is one of the most common targets for adverse drug reactions .
• To determine the cause of the eruption, a logical approach based on clinical characteristics, chronologic factors and a literature search is required .
• Exanthematous eruptions and urticaria are the two most common forms of cutaneous drug reactions .
• When an exanthematous eruption is associated with fever, lymphadenopathy and/or edema of the face, the possibility of DRESS must be considered and an evaluation for systemic involvement conducted .
• Less common drug reactions include fixed, lichenoid, pustular, photo-, bullous and. vasculitic reactions, as well as Stevens–Johnson syndrome and toxic epidermal necrolysis
• Early withdrawal of all potentially responsible drugs is essential, particularly in the case of severe drug reactions.

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